AI-based multiomics profiling for personalized prediction of cardiovascular disease: A prospective UK Biobank study
Author: Yan Luo, Nan Zhang, Jiannan Yang, Mengyao Cui, Kelvin K.F. Tsoi, Gregory Y.H. Lip, Tong Liu, Qingpeng Zhang
Personalized Risk Estimator
Populational Predictive Performance

Instructions

This section shows the personalized cardiovascular disease risk estimator. Please select disease and fill out all fields to calculate risk.

Age (years)
Age must be between 39-70
Sex
Male
Female
Ethnicity
White
Black
Asian
Others
Townsend Deprivation Index
i Measure of material deprivation within a population, higher values indicate greater deprivation.
Value: --
Current Smoking
Yes
No
Daily Alcohol Intake
Yes
No
Healthy Sleep
i Sleep duration ranging between 7 and 9 hours per night.
Yes
No
Physical activity
i At least 150 minutes of walking or moderate activity per week or 75 minutes of vigorous activity (2017 UK Physical activity guidelines).
Yes
No
Healthy diet
i At least 4 of the following 7 criteria:
  • Vegetables: ≥3 servings/day;
  • Fruits: ≥3 servings/day;
  • Fish: ≥2 servings/week;
  • Processed meats: ≤1 serving/week;
  • Unprocessed red meats: ≤1.5 servings/week;
  • Whole grains: ≥3 servings/day;
  • Refined grains: ≤1.5 servings/day.
Yes
No
Social connection
i No more than one of the following criteria:
  • Living alone;
  • Friends and family visit less than once a month;
  • No participation in social activities at least weekly.
Yes
No
Family History of Heart Disease
i Father, mother, or siblings ever had heart disease.
Yes
No
Family History of Stroke
i Father, mother, or siblings ever had stroke.
Yes
No
Family History of Hypertension
i Father, mother, or siblings ever had hypertension.
Yes
No
Family History of Diabetes
i Father, mother, or siblings ever had diabetes.
Yes
No
History of Hypertension
Yes
No
History of Diabetes
Yes
No
Lipid-lowering Medication
Yes
No
Antihypertensive Medication
Yes
No
Systolic Blood Pressure (mmHg)
Diastolic Blood Pressure (mmHg)
Height (cm)
Weight (kg)
Waist Circumference (cm)
Waist-Hip Ratio
Body Mass Index (kg/m^2)
Leukocyte Count (10^9 cells/L)
Lymphocyte Count (10^9 cells/L)
Monocyte Count (10^9 cells/L)
Neutrophill Count (10^9 cells/L)
Eosinophill Count (10^9 cells/L)
Basophill Count (10^9 cells/L)
Platelet Count (10^9 cells/L)
Haematocrit (%)
Haemoglobin (g/dL)
Polygenic Risk Score
Value: --
MetScore
Value: --
ProScore
Value: --
Note: Townsend Deprivation Index, Polygenic Risk Score, MetScore, and ProScore are relative values. The values selected by users will be mapped to the corresponding percentiles of the actual population distribution. Generally, the higher the percentile, the higher the disease risk.

Instructions

This section shows the predictive performance of models trained on various combinations of polygenic risk score (PRS), MetScore, ProScore, and three predefined clinical predictor sets (i.e., AgeSex, Clin, and PANEL). Please select cardiovascular disease and predictor.

Model Performance Comparison

Model Outcome Mean C-index 95% Confidence Interval